Goldfrank's Toxicologic Emergencies
Ninth Edition

by: Lewis S. Nelson, Neal A. Lewin, Mary Ann Howland, Robert S. Hoffman, Lewis R. Goldfrank, Neal E. Flomenbaum,

Buy the Book

Table of contents

Table of contents

Table of Antidotes in Depth

Contributors

Preface

Acknowledgments

1. Historical Principles and Perspectives, Paul M. Wax 2. Toxicologic Plagues and Disasters in History, Paul M. Wax

PART A: THE GENERAL APPROACH TO MEDICAL TOXICOLOGY

3. Initial Evaluation of the Patient: Vital Signs and Toxic Syndromes, Lewis S. Nelson, Neal A. Lewin, Mary Ann Howland, Robert S. Hoffman, Lewis R. Goldfrank, and Neal F. Flomenbaum

4. Principles of Managing the Acutely Poisoned or Overdosed Patient, Lewis S. Nelson, Neal A. Lewin, Mary Ann Howland, Robert S. Hoffman, Lewis R. Goldfrank, and Neal F. Flomenbaum

5. Diagnostic Imaging, David T. Schwartz

6. Laboratory Principles, Petrie M. Rainey

7. Techniques Used to Prevent Gastrointestinal Absorption, Anne-Bolette J. Christophersen and Lotte C.G. Hoegberg

A1. Syrup of Ipecac, Mary Ann Howland

A2. Activated Charcoal, Mary Ann Howland

A3. Whole-Bowel Irrigation and Other Intestinal Evacuants, Mary Ann Howland

8. Pharmacokinetic and Toxicokinetic Principles, Mary Ann Howland

9. Principles and Techniques Applied to Enhance Elimination, David S. Goldfarb 10. Use of The Intensive Care Unit, Mark A. Kirk

PART B: THE FUNDAMENTAL PRINCIPLES OF MEDICAL TOXICOLOGY

Section 1: Biochemical and Molecular Basis

11. Chemical Principles, Stephen J. Traub and Lewis S. Nelson

12. Biochemical and Metabolic Principles, Kurt C. Kleinschmidt and Kathleen A. Delaney

13. Neurotraansmitters and Neuromodulators, Steven C. Curry, Kirk C. Mills, Anne-Michalle Ruha, and Ayrn D. O'Connor 14. Withdrawal Principles, Richard J. Hamilton

Section 2: Pathophysiologic Basis: Organ Systems

15. Thermoregulatory Principles, Susi U. Vassallo and Kathleen A. Delaney

16. Fluid, Electrolyte, and Acid-Based Principles, Alan N. Charney and Robert S. Hoffman

17. Psychiatric Principles, Kishor Malavade and Mark R. Serper

18. Neurologic Principles, Rama B. Rao

19. Ophthalmic Principles, Adhi Sharma

20. Otolaryngologic Principles, William K. Chiang

21. Respiratory Principles, Andrew Stolbach and Robert S. Hoffman

22. Electrophysiologic and Electrocardiographic Principles, Cathleen Clancy

23. Hemodynamic Principles, Robert A. Hessler

24. Hematologic Principles, Marco L.A. Sivilotti

25. Gastrointestinal Principles, Richard J. Church and Kavita M. Babu

26. Hepatic Principles, Kathleen A. Delaney

27. Renal Principles, Donald A. Feinfeld and Nikolas B. Harbord

28. Genitourinary Principles, Jason Chu 29. Dermatologic Principles, Neal A. Lewin and Lewis S. Nelson

Section 3: Special Populations

30. Reproductive and Perinatal Principles, Jeffrey S. Fine

31. Pediatric Principles, Jeffrey S. Fine

32. Geriatric Principles, Judith C. Ahronheim and Mary Ann Howland

33. Postmortem Toxicology, Rama B. Rao and Mark Flomenbaum SC1. Organ Procurement from Poisoned Patients, Rama B. Rao

PART C: THE CLINICAL BASIS OF MEDICAL TOXICOLOGY

Section 1: Case Studies

A. Analgesics and Antiinflammatory Medications

34. Acetaminophen, Robert G. Hendrickson

A4. N-Acetylcysteine, Mary Ann Howland and Robert G. Hendrickson

35. Salicylates, Neal E. Flomenbaum

A5. Sodium Bicarbonate, Paul M. Wax

36. Nonsteroidal Antiinflammatory Drugs, William J. Holubek

37. Colchicine, Podophyllin, and the Vinca Alkoloids, Joshua G. Schier

SC2. Intrathecal Administration of Xenobiotics, Rama B. Rao

38. Opioids, Lewis S. Nelson and Dean Olsen

A6. Opioid Antagonists, Mary Ann Howland and Lewis Nelson

B. Foods, Dietary and Nutritional Agents

39. Dieting Agents and Regimens, Jeanna M. Marraffa

40. Iron, Jeanmarie Perrone

A7. Deferoxamine, Mary Ann Howland

41. Vitamins, Beth Y. Ginsburg

42. Essential Oils, S. Eliza Halcomb

43. Herbal Preparations, Oliver L. Hung

44. Athletic Performance Enhancers, Susi U. Vassallo

45. Food Poisoning, Michael G. Tunik

46. Botulism, Howard L. Geyer

A8. Botulinum Antitoxin, Lewis R. Goldfarb and Howard L. Geyer

C. Pharmaceuticals

47. Anticonvulsants, Suzanne Doyon

A9. L-Carnitine, Mary Ann Howland

48. Antidiabetics and Hypoglycemics, George M. Bosse

A10. Dextrose, Larissa I. Velez and Kathleen A. Delaney

A11. Octreotide, Mary Ann Howland

49. Thyroid and Antithyroid Medications, Nicole C. Bouchard

50. Antihistamines and Decongestants, Anthony J. Tomassoni and Richard S. Weisman

A12. Physostigmine Salicylate, Mary Ann Howland

51. Antimigraine Medications, Jason Chu

52. Antineoplastics Overview, Richard Y. Wang

53. Antineoplastics: Methotrexate, Richard Y. Wang

A13. Leucovorin (Folinic Acid) and Folic Acid, Mary Ann Howland

A14. Glucarpidase, (Carboxypeptidas G2), Silas W. Smith

SC3. Extravasation of Xenobotics, Richard Y. Wang

54. Miscellaneous Antineoplastics, Richard Y. Wang

55. Pharmaceutical Additives, Sean P. Nordt and Lisa E. Vivero

D. Antimicrobials

56. Antibacterials, Antifungals, and Antivirals, Christine M. Stork

57. Antituberculous Medications, Christina H. Hernon and Edward W. Boyer

58. Antimalarials, J. Dave Barry

E. Cardiopulmonary Medications

59. Anticoagulants, Mark Su

A16. Vitamin K, Mary Ann Howland

A17. Protamine, Mary Ann Howland

60. Calcium Channel Blockers, Francis DeRoos

A18. Insulin-Eyglycemia Therapy, William Kerns II

61. B-Adrenergic Antagonists, Jeffrey R. Brubacher

A19. Glucagon, Mary Ann Howland

62. Other Antihypertensives, Francis DeRoos

63. Antidysrhythmics, Lewis S. Nelson and Neal A. Lewin

64. Cardioactive Steroids, Jason B. Hack

A20. Digoxin-Specific Antibody Fragments, Mary Ann Howland

65. Methylxanthines and Selective B2 Adrenergic Agonists, Robert J. Hoffman

F. Anesthetics and Related Medications

66. Local Anesthetics, David R. Schwartz and Brian Kaufman

A21. Intravenous Fat Emulsions, Todd Bania

67. Inhalational Anesthetics, Brian Kaufman and Martin Griffel

68. Neuromuscular Blockers, Kenneth M. Sutin

A22. Dantrolene Sodium, Kenneth M. Sutin

G. Psychotropic Medications

69. Antipsychotics, David Juurlink

70. Lithium, Howard A. Greller

71. Monoamine Oxidase Inhibitors, Alex F. Manini

72. Serotonin Reuptake Inhibitors and Atypical Antidepressants, Christine M. Stork

73. Cyclic Antidepressants, Erica L. Liebelt

74. Sedative-Hynotics, David C. Lee and Kathy Ferguson

A23. Flumazenil, Mary Ann Howland

H. Substances of Abuse

75. Amphetamines, William K. Chiang

76. Cocaine, Jane M. Prosser and Robert S. Hoffman

SC4. Internal Concealment of Xenobiotics, Jane M. Prosser

A24. Benzodiazepines, Robert S. Hoffman, Lewis S. Nelson, and Mary Ann Howland

77. Ethanol, Luke Yip

A25. Thiamine Hydrochloride, Robert S. Hoffman

78. Ethanol Withdrawal, Jeffrey Gold and Lewis S. Nelson

79. Disulfiram and Disulfiram-Like Reactions, Edwin K. Kuffner

80. Y-Hydroxybutyric Acid, Brenna M. Farmer

81. Inhalants, Heather Long

82. Hallucinogens, Kavita M. Babu

83. Cannabinoids, Michael A. McGuigan

84. Nicotine, Sari Soghoian

85. Phencyclidine and Ketamine, Ruben Olmedo

86. Aluminum, Brenna M. Farmer

I. Metals

87. Antimony, Asim F. Tarabar

88. Arsenic, Stephen W. Munday and Marsha Ford

A26. Dimercaprol (British Anti-Lewisite or Bal), Mary Ann Howland

89. Bismuth, Rama B. Rao

90. Cadmium, Stephen J. Traub and Robert s. Hoffman

91. Chromium, Steven B. Bird

92. Cobalt, Gar Ming Chan

93. Copper, Lewis S. Nelson

94. Lead, Fred M. Henretig

A27. Succimer (2,3-Dimercaptosuccinic Acid), Mary Ann Howland

A28. Edetate Calcium Disodium (CaNa2EDTA), Mary Ann Howland

95. Manganese, Sari Soghoian

96. Mercury, Young-Jin Sue

97. Nickel, John Curtis and David A. Haggerty

98. Selenium, Diane P. Calello

99. Silver, Melisa W. Lai Becker and Michele Burns Ewald

100. Thallium, Maria Mercurio and Robert S. Hoffman

A29. Prussian Blue, Robert S. Hoffman

101. Zinc, J. Household Products, Nima Majlesi

102. Antiseptics, Disinfectants, and Sterilants, Paul M. Wax

103. Camphor and Moth Repellents, Edwin K. Kuffner

104. Caustics, Jessica A. Fulton

105. Hydrofluoric Acid and Fluorides, Mark Su

A30. Calcium, Mary Ann Howland

106. Hydrocarbons, David D. Gummin

107. Toxic Alcohols, Sage W. Wiener

SC5. Diethylene Glycol, Joshua G. Schier

A31. Fomepizole, Mary Ann Howland

A32. Ethanol, Mary Ann Howland

K. Pesticides

108. Pesticides: An Overview with a Focus on Principles and Rodenticides, Neal F. Flomenbaum

109. Barium, Andrew Dawson

110. Sodium Monofluoroacetate and Fluroacetamide, Fermin Barrueeto Jr.

111. Phosphorus, Michael Beuhler

112. Strychnine, Yiu-Cheung Chan

113. Insecticides: Organic Phosphorus Compounds and Carbamates, Michael Eddleston and Richard F. Clark

A33. Pralidoxmine, Mary Ann Howland

A34. Atropine, Mary Ann Howland

114. Insecticides: Organic Chlorines, Pyrethrins/Pyrethroids, and Insect Repellents, Michael G. Holland

115. Herbicides, Darren M. Roberts

116. Methyl Bromide and Other Fumigants, Keith K. Burkhart

L. Natural Toxins and Envenomations

117. Mushrooms, Lewis R. Goldfrank

118. Plants, Mary Palmer and Joseph M. Betz

119. Arthropods, In-Hei Hahn

A35. Antivenom (Scorpion and Spider), Richard F. Clark

120. Marine Envenomations, D. Eric Brush

121. Snakes and Other Reptiles, Bradley D. Riley, Anthony F. Pizon, and Anne-Michelle Ruha

A36. Antivenom (Crotaline and Elapid), Anthony F. Pizon, Bradley D. Riley, and Anne-Michelle Ruha

M. Occupational and Environmental Toxins

122. Industrial Poisoning: Information and Control, Peter H. Wald

123. Nanotoxicology, Silas W. Smith

124. Simple Asphyxiants and Pulmonary Irritants, Lewis Nelson and Oladapo Obujebe

125. Carbon Monoxide, Christian Tomaszewski

A37. Hyperbaric Oxygen, Stephen R. Thom

126. Cyanide Andhydrogen Sulfide, Christopher P. Hostege, Gary E. Isom, and Mark A. Kirk

A38. Sodium and Amyl Nitrites, Mary Ann Howland

A39. Sodium Thiosulfate, Mary Ann Howland

A40. Hydroxocobalamin, Mary Ann Howland

127. Methemoglobin Inducers, Dennis P. Price

A41. Methylene Blue, Mary Ann Howland

128. Smoke Inhalation, Nathan Charlton and Mark A. Kirk

N. Disaster Preparedness

129. Risk Assessment and Risk Communications, Charles McKay, Jr.

130. Hazmat Incident Response, Bradley Kaufman

131. Chemical Weapons, Jeffrey R. Suchard

132. Biological Weapons, Jeffrey R. Suchard

133. Radiation, Joseph Rella

A42. Potassium Iodide, Joseph Rella

A43. Pentetic Acid (Dtpa) or Pentetate (Zinc or Calcium) Trisodium, Joseph Rella

Section 2: Poison Centers and Epidemiology 134. Poison Prevention and Education, Lauren Schwartz

135. Poison Centers and Poison Epidemiology, Robert S. Hoffman

136. International Perspectives on Toxicology, Michael Eddleston

137. Principles of Epidemiology and Research Design, Kevin C. Osterhoudt

138. Adverse Drug Events and Postmarketing Surveillance, Louis R., Cantilena

139. Medication Safety and Adverse Drug Events, Brenna M. Farmer

140. Risk Management and Legal Principles, Barbara M. Kirrane and Dainius A. Drukteinis

Index

Download Table of Contents - complete (PDF)